Description

Uses Brorphine online

New psychoactive substances continue to appear on the drug market. Until recently, new synthetic opioids, which are among the most dangerous new psychoactive substances, primarily encompassed analogs of the potent analgesic fentanyl. Lately, also other new synthetic opioids have increasingly started to surface. This is the first report on the identification and full chemical characterization of brorphine, a novel potent synthetic opioid with a piperidine benzimidazolone structure. A powder, identifie as brorphine, was obtaine from a patient seek medical help for detoxification. Brorphine was also found in a serum sample of the patient.

Liquid chromatography-high-resolution mass spectrometry (LC-HRMS) identifie an exact mass of m/z 400.1020 and 402.1005 for the compound, corresponding to both bromine isotopes. Further chemical characterization was performe by gas chromatography-mass spectrometry, liquid chromatography-diode array detection and Fourier-transform infrare spectroscopy analyse.

Finally, the structure was confirme by perform 1H-NMR and 13C-NMR spectroscopy. In vitro biological activity of brorphine was determine by a cell-base opioid receptor activation assay, result in an EC50 of 30.9 nM (13.5 ng/mL) and an Emax of 209% relative to hydromorphone, confirm the high potency and efficacy of this compound.

The presence of opioid activity in the serum was also confirme via the activity-base opioid screen assay. The occurrence of brorphine is yet another example of how the illicit drug market is continuously evolv in an attempt to escape international legislation. Its high potency pose a seriou and imminent health threat for any user.

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As discussed in the background section, brorphine is temporarily controlle in schedule I of the CSA upon the Acting Administrator find it poses imminent hazar to the public safety. Brorphine has a pharmacological profile similar to fentanyl (schedule II) and other schedule I and II synthetic opioids that act as mu-opioid receptor agonists.

Because of the pharmacological similarities of brorphine to heroin (schedule I) and fentanyl (schedule II), a potent mu-opioid agonist, the use of brorphine presents a high risk of abuse and has negatively affected users and communities.

The positive identification of this substance in many post-mortem cases is a serious concern to the public safety.

Law enforcement report demonstrate that  is be illicitly distribute and abuse. According to the National Forensic Laboratory Information System (NFLIS-Drug) database, which collects drug identification results from drug cases submitted to and analyzed by Federal,