Description

4-HO-DET

4-Hydroxy-N,N-diethyltryptamine (also known as 4-HO-DET, CZ-74, and Ethocin) is a lesser-known synthetic psychedelic of the tryptamine chemical class that produces psilocin-like psychedelic effects when adminstered. 4-HO-DET is a close structural and functional analog of psilocin (4-HO-DMT), the principal psychoactive component in magic mushrooms. It is notable for sharing many of its core features while retaining subtle variations in its duration, visual, cognitive and bodily effects.

This compound was first discovered in the late 1950s by Albert Hofmann and Franz Troxler in their investigation of various psychedelic compounds that were structurally and chemically related to the principle active components he isolated from magic mushrooms, psilocybin (4-PO-DMT) and psilocin (4-HO-DMT). The substance was use together with its phosphoryloxy-analog 4-PO-DET in human clinical trial in the  by the German researchers Hanscarl Leuner and G. Baer.[citation needed]

Since its inception, 4-HO-DET has remained relatively uncommon and has very little documentation of human usage, with the majority of psychedelic users preferring more traditional psychedelics like the psilocybin and psilocin in psilocybin mushrooms, or more recently, 4-AcO-DMT. Today, it is either use as a recreational substance or an entheogen, has no documentation of be sol on the street and is primarily acquire through the use of online research chemical vendor.

Chemistry

4-HO-DET, or 4-hydroxy-N,N-diethyltryptamine, is a synthetic indole alkaloid molecule of the tryptamine chemical class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4-HO-DET is substituted at R4 of its indole heterocycle with a hydroxyl functional group OH−. It also contains two ethyl chains bound to the terminal amine RN of its tryptamine backbone (DET).

4-HO-DET is the lower homolog of 4-AcO-DET, the N-substituted diethyl homolog of 4-HO-DMT (psilocin) and the 4-hydroxy analog of DET.

Pharmacology

Further information: Serotonergic psychedelic
As with its structurally related tryptamines, 4-HO-DET principally acts as a 5-HT2A partial agonist, through which it exerts its psychedelic effects.[citation needed]

However, the role of these interactions and how they result in the psychedelic experience continues to remain an object of scientific

Toxicity and harm potential

Further information: Research chemicals Toxicity and harm potential, and Responsible use § Hallucinogens
The toxicity and long-term health effects of recreational 4-HO-DET use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 4-HO-DET is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 4-HO-DET suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strong  recommende that one use harm reduction practice when us this substance.

Tolerance and addiction potential

4-HO-DET is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulat.Tolerance to the effect of 4-HO-DET is built almost immediately after ingestion. After that, it take about 3 day for the tolerance to be reduce to half and 7 day to be back at baseline (in the absence of further consumption). 4-HO-DET present cross-tolerance with all psychedelic, meaning that after the consumption of 4-HO-DET all psychedelic will have a reduce effect.

Effects

The effect of 4-HO-DiPT are broadly comparable to those of other serotonergic psychedelic such as LSD and psilocybin, but they are distinguishe by their relative brevity. 4-HO-DiPT is orally active at 15-20 mg, and its effects last for 2-3 hours. Shulgin “doubt[s] that there is another psychedelic drug, anywhere, that can match this one for speed, for intensity, for brevity, and sensitive to dose, at least one that is active orally.” An idiosyncratic effect of the drug, also noted by Shulgin, is its tendency to induce tremors.

Some users have reported a minor audio distortion with lower dosages. Higher dosages increase the polarity of the distortion. It is define as being slightly lower in pitch and creat several different effect, such as pitch bend, volume distortion, and rate distortion. As with most DiPT psychedelic, music can become more dissonant and less harmoniou. Users have also reporte a visual distortion widely comparable to the hallucinogen LSD.