Description

O-Desmethyl-cis-tramadol General description

O-Desmethyl-cis-tramadol is the primary, active metabolite of tramadol. marketed as the opioid analgesic Ultram or Tramal.for the treatment of moderate to evere pain. This new stable-labeled internal standard is suitable for the quantitation . O-Desmethyl-cis-tramadol in biological samples. the using GCMS or LCMS with numerous applications.this including forensic or clinical toxicology analysis, urine drug testing, or isotope dilution methods.

D-058 / D-058-1ML updated item number format
O-Desmethyl-cis-tramadol-D6 HCl
100 ug/mL (as free base) in Methanol | Certified Reference Material
O-Desmethyl-cis-tramadol is active metabolite of tramadol, marketed as the opioid analgesic Ultram. or Tramal for the treatment of moderate. This new stable-labeled internal standard is suitable for the quantitation of O-Desmethyl-cis-tramadol .in biological samples using GCMS or LCMS with numerous applications.including forensic or clinical toxicology analysi.and urine drug testing, or isotope dilution methods.

O-Desmethyl-cis-tramadol.HCl

[CAS Number 148262-77-5] O-Desmethyl-cis-tramadol hydrochloride is an opioid analgesic and the primary metabolite of cis-tramadol. It is a component drug “Krypton,” is marketed legally in many countries. O-Desmethyl-cis-tramadol.HCl is available as reference material (bulk powder and/or solution) and as calibrated, Ready-to-Use, certified reference material (CRM). This product is designed for qualitative and quantitative protocols. and can be used for forensic, toxicology, research analytical applications.

Effect of Fluconazole on Plasma and Urine Concentrations of Tramadol and Metabolites.
Median (25%–75%) concentration and fluconazole/placebo GMR (90% confidence interval) values for tramadol and metabolites measure in plasma samples 1 and 4 hours after tramadol administration are give  and 4, respectively. Similar summary values for urine samples collected at 4 hours . One hour after tramadol administration the median plasma concentration of show a small but statistic  increase after fluconazole pretreatment compar with placebo pretreatment.

4 hours after tramadol administration. there marke and statistic significant increase in median plasma tramadol. and M1 conjugate concentrations. Conversely, there were mark and statistic significant decrease in median plasma.  M2 conjugate  M5  and M5 conjugate concentrations. There were no changes in tramadol conjugate concentrations.