Description

3-MEO-PCP Pharmacology:

3-MEO-PCP is us tak or and nas, although it may also be smok and
injected. 3-MeO-PCP is already active in the single milligram range and, therefore, accurate dosing
can be a problem. Threshold oral doses start at 1 mg and range up to 30+ mg (considered as heavy
doses). The onset of effects occurs 30–90 minutes after oral ingestion. The duration is 4–8 hours
with a peak effect after 2–3 hours. The duration of after-effects ranges from 4 to 48 hours – the. 3-MeO-PCP has a much more rapid
onset and a shorter duration of effects when vaporized or smoked.
3-MeO-PCP undergoes extensive metabolism (at least 30 phase I and II metabolites can be
generated) and its half-life was estimated to be 10–11 hours.
In vitro as well as in vivo studies show that 3-MeO-PCP is an N-methyl-D-aspartate (NMDA)
receptor antagonist. 3-MeO binds to NMDA receptors more effectively than phencyclidine or
ketamine. Like phencyclidine also binds to the serotonin transporter. It also binds
effectively to the σ1 receptor.

Adverse reactions in humans:

Information is available from published case reports (on severe and
fatal intoxications), from the United Nations Office on Drugs and Crime (UNODC) Early Warning
Advisory (EWA) Tox-Portal and various Internet sources. These reports show that 3-MeO-PCP can
cause acute behavioural, emotional, motivational, cognitive and somatosensory, and motoric
changes, as well as cardiovascular effects including hypertension and tachycardia. At higher doses,
acute intoxication can lead to psychotic behaviour, amnesia and emergency department
admissions or even death.

Chemistry:

Based on its structure, 3-MeO-PCP is an arylcyclohexylamine and 3-methoxy derivative
of phencycSide effects 3-hydroxyphenazepam ?lidine (PCP, a substance controlled under Schedule II of the 1971 UN Convention on
Psychotropic Substances). Three positional isomers (2-, 3- and 4-MeO-PCP) have been identified.
These structural isomers can be differentiated by analytical forensic methods. 3-MeO-PCP can be
synthesized via at least one standard procedure within a few days, from standard starting
materials, reagents and solvents that can be obtained from various chemical companies.