Inspect parenteral drug products visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

Dosing for the Treatment of Clinically Important

Ephedrine Powderb sulfate injection shoul be administere by traine healthcare provider.

The recommended dosages for the treatment of clinically important hypotension in the setting of anesthesia is an initial dose of 5 to 10 mg administered by intravenous bolus. Administer additional boluses as needed, not to exceed a total dosage of 50 mg.

Adjust dosage according to the blood pressure goal (i.e., titrate to effect).

Prepare a 5 mg/mL Solution for Bolus Intravenous Administration

For bolus intravenous administration, prepare a solution containing a final concentration of 5 mg/mL of ephedrine sulfate injection:

Withdraw 50 mg (1 mL of 50 mg/mL) of ephedrine sulfate injection and dilute with 9 mL of 5% Dextrose Injection or 0.9% Sodium Chloride Injection.Withdraw an appropriate dose of the 5 mg/mL solution prior to bolus intravenous administration.

Pressor Effect with Concomitant Oxytocic Drugs

Serious postpartum hypertension has been describe in patient who receive both a vasopressor (i.e., methoxahttps://durapharmacy.com/mine, phenylephrine, ephedrine) and an oxytocic (i.e., methylergonovine, ergonovine) [see Drug Interaction . Some of these patient experience a stroke. Carefully monitor the blood pressure of individual who have receive both ephedrine and an oxytocic.

Tolerance and Tachyphylaxis

Data indicate that repeated administration of ephedrine can result in tachyphylaxis. Clinician treat anesthesia-induce hypotension with ephedrine sulfate injection shoul be aware of the possibility of tachyphylaxi and shoul be prepare with an alternative pressor to mitigate unacceptable responsiveness.

Risk of Hypertension When Used Prophylactically

When use to prevent hypotension, ephedrine has been associate with an increase incidence of hypertension compare. with when ephedrine is use to treat hypotension.