Description

5-MeO-DALT

5-MeO-DALT or N,N-di allyl-5-methoxy tryptamine is a psychedelic tryptamine first synthesized by Alexander Shulgin.

Chemistry

The full name of the chemical is N-allyl-N-[2-(5-methoxy-1H-indol-3-yl)ethyl] prop-2-en-1- amine. It is related to the compounds 5-MeO-DPT and DALT.

In April 2020, Chadeayne et al. solved the crystal structure of the freebase form of 5-MeO-DALT.

History

The first material regar the synthesi and effect of 5-MeO-DALT was sent from Alexander Shulgin to a research associate named Murple in May 2004, after which it was circulate online. In June 2004 5-MeO-DALT became available from internet research chemical vendor after be synthesize by commercial laboratories in China. In August 2004 the synthesis and effect of 5-MeO-DALT were publishe by Erowid.^[6]

Dosage

Dose rang from 12–20 mg were teste by Alexander Shulgin’s research group.

Therapeutic use

Numerous anecdotal reports and a small-scale trial indicate the potential of 5-MeO-DALT for the treatment of cluster headache, one of the most excruciating conditions known to medicine. These observations are consistent with evidence of efficacy of other chemically-related indoleamines in the treatment of cluster headache.

Side effects

There is no published literature on the toxicity of 5-MeO-DALT.

Pharmacology

5-MeO-DALT binds to 5-HT_1A, 5-HT_1D, 5-HT_1E, 5-HT_2A, 5-HT_2B, 5-HT_2C, 5-HT₆, α_2A, α_2B, α_2C, H₁, κ-opioid, σ₁ and σ₂ receptors with K_i values lower than 10μM and also acts as a DAT and SERT monoamine reuptake inhibitor.

5-MeO-DALT acts as a 5-HT_2A partial agonist. The psychedelic effects are believe to come from its efficacy at the 5-HT_2A receptors. However, the role of these interactions and how they result in the psychedelic experience remains the subject of ongoing scientific investigation.

5-MeO-DALT has been use as an intermediate in the preparation of radiolabele diethyltryptamine.

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they shoul be view with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include