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Percocet 10mg/650mg

$325.00$685.00

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should be use with extreme caution in patients with acute asthma, chronic obstructive pulmonary
disorder (COPD), cor pulmonale, or preexisting respiratory impairment. In such patients, even usual
therapeutic doses of oxycodone may decrease respiratory drive to the point of apnea. In these
patients alternative non-opioid analgesics should be considered, and opioids should be employed
only under careful medical supervision at the lowest effective dose.
In case of respiratory depression, a reversal agent such as naloxone hydrochloride may be utilized
(see OVERDOSAGE).
Head Injury and Increased Intracranial Pressure
The respiratory depressant effects of opioids include carbon dioxide retention and secondary
elevation of cerebrospinal fluid pressure, and may be markedly exaggerate in the presence of head
injury, other intracranial lesions or a pre-existing increase in intracranial pressure. Oxycodone
produces effects on pupillary response and consciousness which may obscure neurologic signs of
worsening in patients with head injuries.

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