Fluetizolam

Description

BRIEF DESCRIPTION

Benzodiazepines are central nervous
system depressants. Novel benzodiazepines, typically defined as emergent benzodiazepines not
used medicinally, are often pirated from early drug discovery or pharmaceutical studies. Novel
benzodiazepines have appeared on illicit drug markets in recent years and have caused adverse
events, as described in the literature; fatalities linked to novel benzodiazepine use have occurred,
commonly when used in combination with other depressants (e.g., opioids and alcohol).
Fluetizolam is structurally similar to etizolam and other novel benzodiazepines.

Metabolism: 

Fluetizolam is extensivel metabolize into an active metabolite α-hydroxyetizolam by the process of hydroxylation. The active metabolite also has an action similar to that of fluetizolam. CYP3A4 is the major cytochrome enzyme responsible for metabolism. The inactive metabolite are remove from the body through urine and feces, with the drug’s half-life ranging from 3 to 17 hours.

Duration of Effects: 

Fluetizolam starts to work 15 to 30 minutes after the drug is consumed. The peak concentration is obtained within 30 minutes to 2 hours. The duration of its effects lasts from 5 to 7 hours.

What Is The Dose Of Fluetizolam?

The most commonly used doses of fluetizolam are either 0.5 mg or 1 mg.

This drug is much stronger than average, so it’s important to be very careful and precise when it comes to dosing.

How Does Fluetizolam Work?

Fluetizolam binds to the GABA receptors and potentiates their activity (makes them stronger). When the effect of GABA are enhance neurologic activity is suppress. This results in feelings of calmness, reductions in anxiety levels, and sedation in higher doses.

It also results in impairments in normal cognitive function — such as troubles with memory, difficulty processing complex tasks, and speech impairments.

Benzodiazepine drugs like fluetizolam bind to a special receptor subtype on the GABA-A receptor. This receptor site is situate at the interface between alpha and gamma subunit. The binding of the drug to the alpha-1 subunit causes sedative effects, while binding to the alpha-2, and alpha-3 subunits cause anxiolytic effects. It’s unclear precisely which subtype fluetiz has a higher affinity for. The truth is that the answer could be different for each individual — some users report a strong sedative quality to, while others suggest it’s less sedative than diazepam or other popular alternatives.